| Epitalon Basic information |
| Product Name: | Epitalon |
| Synonyms: | Epitalon;Epithalon;Glycine, L-alanyl-L-a-glutamyl-L-a-aspartyl-;L-alanyl-L-alpha-glutamyl-L-alpha-aspartylglycine;9: PN: WO02090380 PAGE: 55 claimed protein;L-Alanyl-L-α-glutamyl-L-α-aspartylglycine;Epithalon, Epithalon Tetra Peptide;EpithalonAcetate |
| CAS: | 307297-39-8 |
| MF: | C14H22N4O9 |
| MW: | 390.35 |
| EINECS: | 211-519-9 |
| Mol File: | 307297-39-8.mol |
 |
|
| Epitalon Chemical Properties |
| Boiling point | 959.8±65.0 °C(Predicted) |
| density | 1.466±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 250 mg/mL (495.67 mM) |
| pka | 3.16±0.10(Predicted) |
| Epitalon Usage And Synthesis |
| Uses | Epitalon is a synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), that is based on a natural peptide called epithalamin extracted from the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology. |
| benefits | As a result of Epitalon’s effect on telomerase production, the benefits are unique and far-reaching and include: Increases lifespan by lengthening telomeres in human cells Promotes deeper sleep Delays and prevents of age-related diseases such as cancer, heart disease, and dementia Acts as an antioxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function Improves skin health and appearance Heals injured and deteriorating muscle cells Restores and normalizes melatonin levels in those who have lost some pineal function due to aging Can increase resistance to emotional stress |
| Biological Functions | Epitalon was discovered by the Russian scientist Professor Vladimir Khavinson. He researched this peptide of over 35 years in both animal and human clinical trials. The results were astounding. For the first time ever, human clinical trials proved beyond doubt that the substance consisted of powerful life extension and anti-aging possibilities. Benefits of Epitalon: As a result of Epitalon's effect on telomerase production, the benefits are unique and far-reaching and include: An increase of human lifespan by lengthening telomeres in human cells Promotion of deeper sleep Delay and prevention of age-related diseases such as cancer, heart disease, and dementia Acts as an anti-oxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function. Improvement of skin health and appearance Healing of injured and deteriorating muscle cells Restores and normalizes melatonin levels in older people who have lost some pineal function due to aging Can increases resistance to emotional stress |
| Clinical claims and research | Tetrapeptide Epitalon® (Ala–Glu–Asp–Gly) was designed on the basis of Epithalamin amino acid analysis and synthesized at the Laboratory of Peptide Chemistry of the St. Petersburg Institute of Bioregulation and Gerontology.The geroprotective activity of Epitalon was studied in 3 strains of D. melanogaster. Epitalon increased the life-span of imagoes significantly by 11–16% when applied at unprecedentedly low concentrations-from 0.001*10-6 to 5*10-6 wt% of the culture medium. The effective concentrations of Epitalon were 16,000-80,000,000 times lower than those of melatonin. In another experiment, the mean life-span of female VES and male NA-flies increased under the influence of Epitalon by 26%. In NA- females the mean life-span grew by 35% and in NA- males, by 29%. In our recent study the geroprotective effect of long-term Epitalon administration in female CBA mice was demonstrated.54 The number of mice that survived the age of 24 months increased 4 times under Epitalon influence as compared to the controls treated with saline. The bioregulator slowed down aging of the reproductive function, decreased physical activity, inhibited free radical processes, and decreased total spontaneous tumor incidence 1.7 times in female CBA mice.54 Epitalon inhibited mammary carcinogenesis and metastasis in HER-2/neu transgenic mice.55 The expression of HER-2/neu mRNA in the mammary tumors of HER-2/neu transgenic mice treated with Epitalon reduced 3.7-fold in comparison with the control animals. The administration of Epitalon inhibited colon and small intestine carcinogenesis induced by 1,2-dimethylhydrazine in rats. Aging Interventions and Therapies || Pineal Peptides as Modulators of Aging Rattan, Suresh I S |
