| Product Name: | RU 58841 |
| Synonyms: | RU 58841;4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile;4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile;4-[3-(4-Hydroxybutyl)-4,4-diMethyl-2,5-dioxoiMidazolidin-1-yl]-2-(trifluoroMethyl)benzonitrile;RU-58841 E:candyli(at)speedgainpharma(dot)com;CS-637;RU 588841;RU58841;RU 58841;RU-58841 |
| CAS: | 154992-24-2 |
| MF: | C17H18F3N3O3 |
| MW: | 369.34 |
| EINECS: | 1592732-453-0 |
| Product Categories: | Inhibitors;154992-24-2 |
| Mol File: | 154992-24-2.mol |
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| RU 58841 Chemical Properties |
| Boiling point | 493.6±55.0 °C(Predicted) |
| density | 1.39 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml |
| pka | 15.09±0.10(Predicted) |
| form | Powder |
| InChI | InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3 |
| InChIKey | ARBYGDBJECGMGA-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(N2C(=O)N(CCCCO)C(C)(C)C2=O)C=C1C(F)(F)F |
| RU 58841 Usage And Synthesis |
| Androgen receptor | RU58841 (PSK-3841) is a non-steroidal androgen receptor antagonist, initially intended for use in treating prostate cancer. However, it has been found to have a noteworthy impact on aiding hair regrowth. Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS). |
| Uses | RU58841 (Roussel Uclaf) is a nonsteroidal topical antiandrogen without significant systemic effects apparently due to its metabolism in the skin. This appears to be a promising new hair growth agent that promotes hair growth on the scalp as well as retards hair growth of both beard and body hair follicles. RU58841 has produced highly efficacious results in stumptailed macaques. The synergistic effects of RU58841 and minoxidil topical solution (2% and 5%) have also been reported in stumptailed macaques. The effect of combined treatment was most remarkable early on, but by 1 year no significant benefit of combined treatment was apparent relative to either treatment alone. |
