| H-HIS-D-TRP-D-LYS-TRP-D-PHE-LYS-NH2 Basic information |
| Product Name: | H-HIS-D-TRP-D-LYS-TRP-D-PHE-LYS-NH2 |
| Synonyms: | [D-TRP7, D-LYS8, D-PHE10]-ALPHA-MELANOCYTE STIMULATING HORMONE (6-11) AMIDE;(D-TRP7,D-LYS8,D-PHE10)-ALPHA-MSH (6-11) AMIDE;[D-LYS3]-GHRP-6;[D-LYS3]-GHRP-6 [HIS1, D-LYS3, LYS6]-GHRP HIS-D-TRP-D-LYS-TRP-D-PHE-LYS-NH2;[D-LYS3]-GROWTH HORMONE RELEASING PEPTIDE;(D-LYS3)-GROWTH HORMONE-RELEASING PEPTIDE-6;HWKWFK-NH2;[HIS1, D-LYS3, LYS6]-GHRP |
| CAS: | 136054-22-3 |
| MF: | C49H63N13O6 |
| MW: | 930.11 |
| EINECS: | |
| Product Categories: | peptide;Ghrelin receptor;Peptides |
| Mol File: | 136054-22-3.mol |
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| H-HIS-D-TRP-D-LYS-TRP-D-PHE-LYS-NH2 Chemical Properties |
| Boiling point | 1422.5±65.0 °C(Predicted) |
| density | 1.314±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble to 0.50 mg/ml in H2O |
| form | lyophilized powder |
| pka | 13.37±0.46(Predicted) |
| Water Solubility | Soluble in water. |
| Stability: | Hygroscopic |
| H-HIS-D-TRP-D-LYS-TRP-D-PHE-LYS-NH2 Usage And Synthesis |
| Uses | [D-Lys3]-GHRP6 has been used-
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| Biochem/physiol Actions | [D-Lys3]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca2+ and Na+ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH. |
| IC 50 | 0.9 μm |
| storage | Desiccate at -20°C |
| references | [1]. schith hb, muceniece r, wikberg je. characterization of the binding of msh-b, hb-228, ghrp-6 and 153n-6 to the human melanocortin receptor subtypes. neuropeptides. 1997 dec;31(6):565-71. [2]. traebert m, riediger t, whitebread s, scharrer e, schmid ha. ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. j neuroendocrinol. 2002 jul;14(7):580-6. [3]. pinilla l, barreiro ml, tena-sempere m, aguilar e.role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids. neuroendocrinology. 2003 feb;77(2):83-90. |