| Terlipressin acetate Information |
| Product Name: | Terlipressin acetate |
| Synonyms: | [N-α-Triglycyl-8-lysine]-vasopressin;130: PN: WO2010033207 SEQID: 171 claiMed protein;1-Triglycyl-8-lysine Vasopressin;Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, Terlipressine, Terlipressina, Terlipressinum |
| CAS: | 14636-12-5 |
| MF: | C52H74N16O15S2 |
| MW: | 1227.37 |
| EINECS: | 238-680-8 |
| Product Categories: | hormones;Peptide;Amino Acid Derivatives;14636-12-5 |
| Mol File: | 14636-12-5.mol |
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| Terlipressin acetate Chemical Properties |
| Melting point | >170°C (dec.) |
| Boiling point | 1824.0±65.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Pka | 9.90±0.15(Predicted) |
| Form | Solid |
| Color | White |
| InChIKey | BENFXAYNYRLAIU-ITQMCZIINA-N |
| CAS DataBase Reference | 14636-12-5(CAS DataBase Reference) |
| Terlipressin acetate Mechanism of Action And Uses |
Mechanism of Action |
Terlipressin, a synthetic triglycyl-lysine derivative of vasopressin, is a inactive prodrug. It has pressor and antidiuretic effects. Following IV injection, lysine vasopressin are released following the enzymatic cleavage of 3 glycyl moieties. Duration: 4-6 hr. |
Adverse Drug Reactions |
Abdominal cramps, cardiac arrhythmias, headache, transient blanching, increased arterial pressure. Potentially Fatal: MI, cardiac failure. |
Description |
Terlipressin acetate is a novel synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. After the action of aminopeptidase in the body, after removing the three glycyl residues at its N-terminus, it slowly "releases" the active lysine vasopressin. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate. |
| Uses |
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is also used in the treatment of acute variceal bleeding. |
| Definition |
ChEBI: Terlipressin is a polypeptide. |
| Clinical Use | Treatment of bleeding oesophageal varices |
